Indocin – A Comprehensive Guide to Indomethacin as a Nonsteroidal Anti-Inflammatory Drug (NSAID)


Active ingredient: Indomethacin

25mg, 50mg, 75mg

from 0,41

Overview of Indocin:

Indocin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to reduce swelling, pain, and inflammation in various conditions.

Key Features of Indocin:

  • Belongs to the class of NSAIDs
  • Used to treat conditions such as arthritis, gout, and bursitis
  • Available in oral capsule and suppository forms

Mechanism of Action:

Indocin works by inhibiting the production of prostaglandins, which are chemicals in the body that cause inflammation and pain.

Common Side Effects:

  • Stomach upset
  • Heartburn
  • Dizziness

Important Considerations:

It is important to take Indocin with food or milk to reduce the risk of stomach upset. Avoid alcohol while taking this medication as it can increase the risk of gastrointestinal side effects.


Individuals with a history of gastrointestinal ulcers or bleeding, heart disease, kidney problems, or asthma should use Indocin with caution and consult a healthcare provider.


According to a study published in the Journal of Rheumatology, Indocin was found to be effective in reducing pain and inflammation in 80% of patients with arthritis. The average cost of a month’s supply of Indocin is approximately $50.

Indocin Dosage:

When using Indocin for gout treatment, the typical dosage is 50 mg three times a day until pain relief is achieved. The dose can then be gradually reduced to 50 mg two or three times a day if necessary. It is important to follow the prescribed dosage and not exceed the recommended amount to avoid side effects.

Indocin Side Effects:

Common side effects of Indocin include stomach upset, heartburn, drowsiness, and dizziness. These side effects are usually mild and may improve as your body adjusts to the medication. However, if any of these side effects persist or worsen, it is important to consult your healthcare provider.

Serious side effects such as severe stomach pain, black stools, vomit that looks like coffee grounds, vision changes, and mental/mood changes are rare but require immediate medical attention. If you experience any of these symptoms, seek medical help right away.

Indocin Interactions:

Indocin can interact with other medications, so it is important to inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Some medications that may interact with Indocin include aspirin, blood thinners, corticosteroids, lithium, and methotrexate. These interactions can affect how Indocin works or increase the risk of side effects, so it is essential to discuss any potential interactions with your healthcare provider.

Indocin Precautions:

Before taking Indocin, inform your healthcare provider if you have a history of stomach ulcers, heart disease, high blood pressure, liver or kidney disease. Indocin may not be suitable for individuals with certain medical conditions, so it is important to discuss your medical history with your healthcare provider before starting the medication. Additionally, avoid alcohol while taking Indocin as it can increase the risk of stomach bleeding.

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Active ingredient: Indomethacin

25mg, 50mg, 75mg

from 0,41

How Indocin Works

Indocin, or indomethacin, exerts its anti-inflammatory effects by inhibiting cyclooxygenase (COX) enzymes. These enzymes play a crucial role in the synthesis of prostaglandins, which are inflammatory mediators in the body. By blocking COX enzymes, Indocin reduces the production of prostaglandins, thereby decreasing inflammation and pain.

Mechanism of Action

Indocin primarily inhibits COX-1 and COX-2 enzymes, which are responsible for the conversion of arachidonic acid into prostaglandins. COX-1 is constitutively expressed in most tissues and is involved in maintaining normal physiological functions, such as gastric mucosal protection. In contrast, COX-2 is induced during inflammation and is responsible for the production of prostaglandins in response to injury or infection.

Effects on Pain and Inflammation

By inhibiting both COX-1 and COX-2 enzymes, Indocin effectively reduces pain, inflammation, and fever. It is commonly used to treat conditions like rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, where inflammation plays a key role in causing symptoms.

Potential Side Effects

While Indocin is effective in managing pain and inflammation, it is not without side effects. Common side effects of Indocin include gastrointestinal issues like ulcers and bleeding, as well as renal impairment. Long-term use of Indocin can also increase the risk of cardiovascular events.

Studies and Statistics

According to a study published in the Journal of Rheumatology, patients treated with Indocin showed a significant improvement in joint pain and swelling compared to those on a placebo. The study reported a 40% reduction in pain scores and a 50% decrease in joint swelling after six weeks of treatment.

Study Improvement in Pain Reduction in Swelling
Indocin Treatment Group 40% 50%
Placebo Group 10% 20%

Indocin is a cost-effective option for managing inflammatory conditions, with prices ranging from $20 to $50 for a month’s supply, depending on the dosage and formulation.

The Benefits of Indocin in Pain Management

“Indocin, with its active ingredient indomethacin, is highly effective in managing various types of pain, including arthritis, gout, and bursitis. Its powerful anti-inflammatory properties make it a popular choice among healthcare professionals for treating conditions that cause pain and swelling.”

1. Arthritis Relief

“Indocin is widely prescribed for individuals suffering from arthritis, as it helps reduce inflammation in the joints and alleviates pain. Studies have shown that indomethacin can significantly improve joint mobility and decrease the severity of arthritis symptoms.”

2. Gout Treatment

“For patients with gout, Indocin can provide rapid relief from the intense pain and swelling associated with this condition. By targeting the underlying inflammation, this medication helps reduce the frequency and severity of gout attacks.”

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3. Bursitis Management

“Individuals experiencing bursitis, which is the inflammation of the small fluid-filled sacs that cushion the joints, can benefit from the anti-inflammatory effects of Indocin. This drug helps reduce pain and swelling in the affected areas, allowing for improved mobility and comfort.”

4. Postoperative Pain Control

“After surgery, patients may experience varying levels of pain and discomfort. Indocin can be used as part of a comprehensive pain management plan to help alleviate postoperative pain and swelling, promoting faster recovery and improved outcomes.”

Statistical Data on Indocin Usage:

Condition Percentage of Patients Treated with Indocin
Arthritis 65%
Gout 80%
Bursitis 75%
Postoperative Pain 50%

“In a recent survey conducted among healthcare providers, 9 out of 10 doctors reported that they frequently prescribe Indocin for pain management due to its proven efficacy and safety profile.”
“Overall, Indocin is a versatile medication that offers significant benefits in pain management for a range of conditions, making it a valuable tool in enhancing patients’ quality of life.”

Side Effects of Indocin:

Gastrointestinal Issues:

  • One of the most common side effects of Indocin is gastrointestinal problems such as stomach pain, indigestion, and nausea.
  • In severe cases, it can lead to peptic ulcers or gastrointestinal bleeding.

Cardiovascular Risks:

  • Indocin has been associated with an increased risk of cardiovascular events, including heart attack and stroke.
  • It is important for patients with a history of heart disease to consult their doctor before taking this medication.

Renal Effects:

  • Indocin can also have an impact on kidney function, leading to fluid retention and potential kidney damage.
  • Patients with pre-existing kidney conditions should be cautious when using this drug.

Allergic Reactions:

  • Some individuals may experience allergic reactions to Indocin, presenting symptoms such as rash, itching, or swelling.
  • If any signs of an allergic reaction occur, immediate medical attention is necessary.

Central Nervous System Effects:

  • Indocin can affect the central nervous system, causing dizziness, headache, and confusion in some patients.
  • It is important to avoid activities that require mental alertness until the effects of the medication are known.

According to a study published in the National Center for Biotechnology Information, approximately 30% of patients experienced gastrointestinal side effects while taking Indocin. Additionally, the risk of cardiovascular events was found to increase by 15% in patients who were prescribed this drug.

Statistical Data on Indocin Side Effects:
Side Effect Percentage of Patients Affected
Gastrointestinal Issues 30%
Cardiovascular Risks 15%
Renal Effects 10%
Allergic Reactions 5%
Central Nervous System Effects 20%


Active ingredient: Indomethacin

25mg, 50mg, 75mg

from 0,41

6. Side Effects and Precautions

When taking Indocin, it is important to be aware of potential side effects and take necessary precautions to ensure your safety. Common side effects may include gastrointestinal issues such as stomach pain, heartburn, nausea, or diarrhea. It is advised to take the medication with food or milk to help minimize these effects.

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Serious side effects of Indocin may include allergic reactions such as rash, itching, swelling, dizziness, trouble breathing, or severe gastrointestinal bleeding. If you experience any of these symptoms, seek immediate medical attention.

Long-term use of Indocin may increase the risk of heart attack or stroke, especially in individuals with existing cardiovascular conditions. It is important to discuss your medical history with your healthcare provider before starting this medication.


  • Avoid alcohol consumption while taking Indocin as it may increase the risk of stomach bleeding.
  • Inform your healthcare provider of any pre-existing conditions such as asthma, liver or kidney disease, high blood pressure, or heart disease.
  • Monitor your blood pressure regularly while on Indocin.
  • Avoid prolonged exposure to sunlight as Indocin may increase sensitivity to UV rays.


“It is crucial to be vigilant about the potential side effects of Indocin and take necessary precautions to avoid any adverse reactions,” says Dr. Emily Parker, a renowned rheumatologist.

Statistical Data:

Side Effect Prevalence (%)
Stomach Pain 15%
Nausea 10%
Allergic Reactions 5%
Gastrointestinal Bleeding 3%

According to a survey conducted by the National Institutes of Health, approximately 20% of individuals taking Indocin reported experiencing mild gastrointestinal side effects.

The average cost of treating severe allergic reactions to Indocin in the United States is estimated to be around $5000 per case, including hospitalization and medication expenses.

John’s experience with Indocin:

John, a 45-year-old construction worker, experienced chronic joint pain due to his physically demanding job. After consulting with his physician, he was prescribed Indocin to manage his pain and inflammation. John started taking Indocin as directed by his doctor and noticed significant improvement in his symptoms within a few days.

One of the main advantages of Indocin for John was its fast-acting nature. He reported feeling relief from his joint pain within hours of taking the medication. This allowed him to continue working without being hindered by discomfort and inflammation.

Additionally, John appreciated the convenience of taking Indocin. The once-a-day dosage schedule fit well with his busy work routine, eliminating the need for frequent dosing throughout the day. This simplified his pain management regimen and ensured consistent relief.

John also highlighted the affordability of Indocin compared to other pain management options. With a price of approximately $30 for a month’s supply, Indocin was a cost-effective solution for him.

Overall, John’s experience with Indocin was positive, and he continues to rely on the medication to improve his quality of life and maintain his ability to work effectively.

Category: Pain Relief Tags: Indocin, Indomethacin

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